| Customization: | Available |
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| Powder: | Yes |
| Customized: | Customized |
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Phenolphthalein is a chemical that is commonly used as a colorimetric pH indicator. The compound has been observed to turn orange at pH <0, clear between pH 0-8.2, fuchsia between pH 8.2-12, and clear again at a pH above 12. It has been postulated that the mutagenic effects of Phenolphthalein at high doses can be attributed the enhancement intracellular free oxygen radicals. The compound has also been observed to induce mitotic abnormalities and micronuclei with kinetochores in vitro. In Syrian hamster embryos treated with 10-40 μM of Phenolpthalein a significant number of chromosomal aberrations occurred at the hprt locus. On human breast cancer cells Phenolphthalein has been observed to have weak estrogenic effects.
Uses: acid-base indicator, chromatography reagents, organic synthesis, pharmaceutical industry (such as the manufacture of laxatives)
| Product name | Phenolphthalein |
| Appearance | white Powder |
| Specification | 99% |
| Shelf life | 2 years when properly stored |
Function and Application
Pharmacological effects
Phenolphthalein irritating laxatives, the main role in the large intestine. After oral administration in the intestinal alkaline environment to
form soluble sodium salt, stimulate the plexus wall plexus, a direct role in the intestinal smooth muscle, so that peristalsis increased.
At the same time phenolphthalein and inhibit intestinal absorption of water, so that water and electrolyte accumulation in the colon,
resulting laxation effect. The role of strength and intestinal size of alkaline, and its role in mild, rarely cause intestinal spasm.
Pharmacokinetics
Phenolphthalein after oral 6 ~ 8h effect. About 15% of oral absorption after absorption of drugs mainly in the form of glucuronide by the
kidneys or excretion of excreted, some can also be excreted to the intestine by the bile, was reabsorbed in the intestine to form enterohepatic
circulation, thereby prolonging the duration of action , So the role of a single administration of sustainable 3 to 4 days. Unabsorbed part is
excreted via feces. Phenolphthalein can also be secreted by milk.
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