Customization: | Available |
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Certification: | ISO, FDA |
Assay Method: | HPLC |
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Name | Honokiol |
CAS No |
35354-74-6
|
Appearance | white powder |
Specification | 98% |
Function
1. The effect of anti-pathogenic microorganisms Magnolia decoction is effective against Gram-positive bacteria such as Staphylococcus, hemolytic streptococcus, pneumococcus, pertussis bacillus, as well as Bacillus anthracis, Shigella, typhoid bacillus, paratyphoid bacillus, and Vibrio cholerae , Escherichia coli, Proteus, Bacillus subtilis, Bacillus diphtheria and other Gram-negative bacteria have inhibitory effect, among which the inhibitory effect on Staphylococcus is the strongest.
2. Effects on the cardiovascular system Magnolol and honokiol inhibit the formation of thromboxane B2 in various conditions, and the increase of intracellular Ca2+ caused by arachidonic acid or collagen is also inhibited by both.
Honokiol can inhibit the activity of CaM-stimulated cyclic nucleotide phosphodiesterase, and in the presence of Ca2+, honokiol can combine with CaM to antagonize its activation of phosphodiesterase. In addition, honokiol has a stimulatory effect on the basal activity of CaM-dependent phosphodiesterases.
3. Antitumor effect Magnolol and its hydroxymethyl derivatives have obvious inhibitory effect on secondary skin tumors in mice.
The three extract components of magnolia bark, lignans, magnolol, honokiol and monoterpene magnolol, are 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced Epstein - Antagonist of Barr virus early antigen (EBv-EA) activation. Magnolia bark methanol extract and magnolol have obvious inhibitory effect on mouse skin tumors induced by phase II carcinogenicity experiments in vivo.
Application
1:As the medicine of anti-inflammatory, antibacterial, antioxidant and anti-tumor drug, it is widely used in the fields of medicine and health products.
2:As a strong antioxidant, it is widely used in cosmetics industry-Magnolol is a powerful antioxidant in cardiovascular diseases