| Customization: | Available |
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| Powder: | Yes |
| Customized: | Customized |
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What is Valrubicin ?
Valrubicin is a chemotherapy drug used to treat bladder cancer.
| Product Name | Best Price Top Quality 99% Raw Valrubicin Powder CAS 56124-62-0 Valrubicin |
| Appearance | White powder |
| CAS | 56124-62-0 |
| Assay | 99% |
| Keywords | Valrubicin;Valrubicin Powder;Valrubicin CAS 56124-62-0 |
| Shelf Life | 24 months when properly stored |
| Storage | Keep in a cool, dry, dark location |
Valrubicin was launched as a new 'chemotherapeutic agent for the treatment of bladder cancer, particularly in patients with BCG-refractory carcinoma in situ (CIS) of the bladder for whom immediate cystectomy is unacceptable. It belongs to the class of anthracyclines, the widest used in human cancers, and is a N-trifluoroacetyl 14-valerate derivative .
Valrubicin can be obtained in 3 steps from daunomycin by N-trifluoroacetylation of the sugar moiety then iodination of the 2-acetyl group and introduction of a valerate residue. A proposed mechanism involved in the cytotoxicity of Valrubicin coud be the blockade of SV40 large T antigen helicase; this cellular enzyme is involved in the formation of a ternary complex with DNA to maintain the topographic structure of DNA during transcription.
In patients with CIS of bladder refractory to front line and second line therapies, intravesical instillation of Valrubicin resulted in a complete response with a significant rate and allowed a delay in cystectomy. Systemic absorption was minimal and accordingly produced a lower incidence of cardiotoxicity compared .
Valrubicin is available in 200-mg vials for intravesicular administrationin the treatment of bladder cancer (orphan drugstatus). The increased lipophilicity associated with the valericacid ester and trifluoro acetate functionalities increasestissue penetration and remains intact because, in large measure,of the lack of exposure to hydrolyzing enzymes causedby direct delivery into the bladder followed by voiding ofthe instilled solution. This local action also minimizes cardiotoxicityand other adverse effects seen with other anthracyclines.The major adverse effects that are seen are bladderirritation and reddening of the urine.
| Pro-xylane | Potassium azeloyl diglycinate |
| Ghk-Cu or other Cosmetic peptides | Glutathione |
| Spermidine | 5-deazaflavin |
| PQQ | Coenzyme Q10 |
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