Factory 99% Pemetrexed Disodium Powder CAS 150399-23-8 Chemical Intermediate

• Customization: Available
• Powder: Yes
• Customized: Customized
• Model NO.: A820
• Certification: GMP, HSE, ISO 9001, USP, BP
• Suitable for: Elderly, Children, Adult
• State: Powder
• Purity: >99%
• Name: Pemetrexed Disodium
• CAS: 150399-23-8
• Appearance: White Powder
• Assay: 99%
• OEM: Available
• Sample: Available
• Suitable: Adult
• MOQ: 1g
• Function: Chemical Intermediate
• Transport Package: Foil Bag
• Specification: 99
• Trademark: /
• Origin: China
• Production Capacity: 10000 Kgs Per Month

Product Description

 

Product Name	Pemetrexed Disodium
Appearance	White Powder
CAS NO.	150399-23-8
Storage	Keep in a cool, dry, dark location

 

Pemetrexed Disodium, also known as LY-231514 disodium, is a novel antifolate and antimetabolite drug. It belongs to a class of compounds that disrupt the normal folate-dependent metabolic processes within cells, thereby inhibiting cell growth.

 

1. Cancer Treatment: Pemetrexed Disodium is primarily used in the treatment of various types of cancer, including malignant pleural mesothelioma, non-small cell lung cancer, and other solid tumors.
2. Combination Therapy: It is often administered in combination with other chemotherapeutic agents, such as cisplatin, to enhance the treatment efficacy and improve patient outcomes.
3. Adjuvant Therapy: In some cases, Pemetrexed Disodium may be used as adjuvant therapy following surgery to prevent cancer recurrence.

1. Antifolate Activity: Pemetrexed Disodium exhibits potent antifolate activity by inhibiting multiple folate-requiring enzymes, such as thymidylate synthetase (TS), dihydrofolate reductase (DHFR), and glyceraldehyde-3-phosphate dehydrogenase (GARFT).
2. Cell Cycle Inhibition: By disrupting folate metabolism, Pemetrexed Disodium disrupts DNA and RNA synthesis, thereby inhibiting cancer cell proliferation and inducing cell cycle arrest.
3. Enhanced Therapeutic Index: Through its selective inhibition of folate-dependent metabolic pathways, Pemetrexed Disodium exhibits a high therapeutic index, making it an effective and relatively safe treatment option for various cancers.