Factory 99% Verapamil HCl Powder CAS 152-11-4 Chemical Intermediate Verapamil HCl

• Customization: Available
• Powder: Yes
• Customized: Customized
• Model NO.: A814
• Certification: GMP, HSE, ISO 9001, USP, BP
• Suitable for: Elderly, Children, Adult
• State: Powder
• Purity: >99%
• Name: Verapamil HCl
• CAS: 152-11-4
• Appearance: White Powder
• Assay: 99%
• OEM: Available
• Sample: Available
• Suitable: Adult
• MOQ: 1g
• Function: Chemical Intermediate
• Transport Package: Foil Bag
• Specification: 99
• Trademark: /
• Origin: China
• Production Capacity: 10000 Kgs Per Month

Product Description

 

Product Name	Verapamil HCl
Appearance	White Powder
CAS NO.	152-11-4
Storage	Keep in a cool, dry, dark location

 

Verapamil HCl is a pharmacological agent defined as an L-type calcium channel blocker with oral activity.

 

1. Cardiovascular Disorders: Verapamil HCl is primarily used in the treatment of various cardiovascular conditions. This includes the management of supraventricular tachycardia, atrial fibrillation, and atrial flutter, where it helps to regulate heart rate and rhythm.
2. Hypertension: It is also prescribed for the treatment of hypertension (high blood pressure), as it helps to dilate blood vessels and reduce peripheral vascular resistance.
3. Other Indications: Additionally, Verapamil HCl has been used in the treatment of angina pectoris, hypertrophic cardiomyopathy, and as a adjunct in the management of myocardial infarction.

1. Calcium Channel Blockade: The primary function of Verapamil HCl is to block the influx of calcium ions into myocardial and vascular smooth muscle cells through L-type calcium channels. This action leads to a decrease in contractility and relaxation of vascular smooth muscle, resulting in vasodilatation and a reduction in blood pressure.
2. Anti-arrhythmic Effects: By blocking calcium channels in the heart, Verapamil HCl prolongs the effective refractory period of the atrioventricular (AV) node, which helps to slow down the conduction of electrical impulses through the heart. This can be useful in treating arrhythmias such as supraventricular tachycardia and atrial fibrillation.
3. Other Mechanisms: Verapamil HCl also has inhibitory effects on P-glycoprotein, an efflux transporter involved in drug resistance, and may have some anti-tumor activity by inhibiting the proliferation of certain cancer cells. Additionally, it has been shown to inhibit the CYP3A4 enzyme, which is important for drug metabolism.