Customization: | Available |
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Powder: | Yes |
Customized: | Customized |
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Product Name | Mesalazine |
Appearance | White Powder |
CAS NO. | 89-57-6 |
MF | C7H7NO3 |
Storage | Keep in a cool, dry, dark location |
Mesalazine is a medication primarily used in the treatment of inflammatory bowel diseases (IBD), specifically ulcerative colitis and, to a lesser extent, Crohn's disease. It belongs to the class of drugs known as aminosalicylates.
Oral Administration: Mesalazine is commonly administered orally in the form of tablets or capsules. It is designed to release the active ingredient in the distal small intestine and colon, where it is most needed to reduce inflammation.
Rectal Administration: For patients with rectal or left-sided ulcerative colitis, mesalazine can be administered rectally in the form of enemas or suppositories. This direct application allows for higher concentrations of the drug to reach the affected area.
Combination Therapy: Mesalazine may be used in combination with other medications, such as corticosteroids or immunosuppressants, to achieve better disease control in severe or refractory cases of IBD.
Anti-inflammatory Action: The primary function of mesalazine is to reduce inflammation in the intestinal mucosa. It works by inhibiting the production of pro-inflammatory cytokines and prostaglandins, which are key mediators of the inflammatory process in IBD.
Mucosal Healing: By reducing inflammation, mesalazine promotes mucosal healing, which is crucial in the management of IBD. Healing of the intestinal lining can lead to improved symptoms, reduced risk of complications, and potentially better long-term outcomes.
Maintenance of Remission: Mesalazine is also effective in maintaining remission, or disease inactivity, in patients with ulcerative colitis. Regular use of the drug can help prevent flares or exacerbations of symptoms, thereby improving quality of life and reducing the need for more aggressive therapies.