| Customization: | Available |
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| Certification: | RoHS, BRC, ISO, FDA, HACCP |
| Assay Method: | HPLC-MS, GPC, HPLC, UV |
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| Product Name | Harmaline |
| Appearance | White Powder |
| CAS NO. | 304-21-2 |
| Molecular Formula | C13H14N2O |
| Storage | Keep in a cool, dry, dark location |
Harmaline, also known as 7-methoxy-1-methyl-4,9-dihydro-3H-pyrido[3,4-b]indole, is an indole alkaloid derived from natural sources, particularly from the plants of the genus Peganum, such as Peganum harmala. It is a naturally occurring compound with a long history of ethnobotanical use and has been the subject of scientific research due to its unique pharmacological properties.
Ethnobotanical and Traditional Use: Harmaline has been used in cultural and religious contexts for its psychoactive and hallucinogenic properties, aiding in altered states of consciousness and spiritual experiences.
Pharmaceutical and Medical Research: Due to its ability to inhibit monoamine oxidase (MAO) enzymes and its effects on serotonergic and dopaminergic neurotransmission, Harmaline is being studied for potential therapeutic applications in the treatment of various medical conditions, including anxiety, depression, and neurodegenerative diseases.
Chemical Synthesis and Derivative Development: Harmaline serves as a valuable starting material in the synthesis of other pharmacologically active compounds and derivatives, contributing to the development of new therapeutic agents.
Psychotropic Activity: Harmaline acts as a serotonergic agonist, influencing mood, perception, and cognitive function. It has been shown to produce psychoactive effects, including hallucinations and altered states of consciousness, when administered in certain doses.
Neuroprotective Effects: Research suggests that Harmaline may have neuroprotective properties, protecting neurons against damage caused by oxidative stress and other neurotoxic agents. This potential makes it a promising candidate for the treatment of neurodegenerative diseases.
Monoamine Oxidase Inhibition: Harmaline functions as a reversible inhibitor of monoamine oxidase (MAO) enzymes, particularly MAO-A and MAO-B. By inhibiting these enzymes, Harmaline increases the levels of neurotransmitters such as serotonin, dopamine, and norepinephrine in the brain, thereby modulating neurotransmission and affecting behavior and mood.
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