Factory 99% Plecanatide Powder CAS 467426-54-6 Chemical Intermediate Plecanatide

• Customization: Available
• Powder: Yes
• Customized: Customized
• Model NO.: A761
• Certification: GMP, HSE, ISO 9001, USP, BP
• Suitable for: Elderly, Children, Adult
• State: Powder
• Purity: >99%
• Name: Plecanatide
• CAS: 467426-54-6
• Appearance: White Powder
• Assay: 99%
• OEM: Available
• Sample: Available
• Suitable: Adult
• MOQ: 1g
• Function: Chemical Intermediate
• Transport Package: Foil Bag
• Specification: 99
• Trademark: /
• Origin: China
• Production Capacity: 10000 Kgs Per Month

Product Description

 

Product Name	Plecanatide
Appearance	White Powder
CAS NO.	467426-54-6
Storage	Keep in a cool, dry, dark location

 

Plecanatide is a uridine guanosine analog and an orally active guanylate cyclase-C (GC-C) receptor agonist. It mimics the natural hormones in the body to promote intestinal motility and improve constipation symptoms.

 

1. Chronic Idiopathic Constipation (CIC) Treatment: Plecanatide is primarily applied in the treatment of CIC in adults. It helps patients restore normal bowel frequency and stool consistency, reducing discomfort caused by constipation.
2. Irritable Bowel Syndrome with Constipation (IBS-C): In addition to CIC, Plecanatide can also be used to treat constipation associated with IBS-C, providing an effective alternative for patients who have not responded well to other treatments.
3. Research and Clinical Trials: Plecanatide is also used in research and clinical trials to explore its potential in treating other gastrointestinal disorders or conditions.

1. GC-C Receptor Activation: Plecanatide activates the GC-C receptors located on intestinal epithelial cells, stimulating the synthesis of cyclic GMP (cGMP). This process enhances water and electrolyte secretion in the intestine.
2. Increased Intestinal Fluid and Motility: By stimulating GC-C receptors, Plecanatide increases intestinal fluid content and motility. This helps to soften stool and promote bowel movements, making it easier for patients to defecate.
3. Anti-inflammatory Activity: Plecanatide has also been shown to have anti-inflammatory activity in animal models of colitis. However, its primary function in clinical practice remains the treatment of constipation.