Manidipine Hydrochloride Powder CAS 89226-75-5 Antihypertensive Manidipine Hydrochloride API Manidipine HCl

• Customization: Available
• Powder: Yes
• Customized: Customized
• Certification: GMP, ISO 9001, USP
• Suitable for: Adult
• State: Powder
• Purity: >99%
• Sample: Available
• OEM: Available
• MOQ: 1kg
• CAS: 89226-75-5
• Keyword: Manidipine HCl
• Keyword 1: Manidipine HCl Powder
• Transport Package: 1kg Foil Bag /25kg Drum
• Specification: 99%
• Trademark: /
• Origin: China
• Production Capacity: 20000

Product Description

Description

Manidipine Dihydrochloride is a metabolite of Manidipine (M16400), a dihydropyridine calcium channel blocker that exhibits antihypertensive properties. Manidipine 2Hcl (CV-4093) is a dihydropyridine compound and a calcium channel blocker for Ca2+ current with IC50 of 2.6 nM. IC50 value: 2.6 nMTarget: calcium channelManidipine is described to block T-type Ca2+ channels specifically and is also described to have a high selectivity for the vasculature, presenting negligible cardiodepression as compared to other Ca2+ channel antagonists. Manidipine is also described to not significantly affect norepinephrine levels, suggesting a lack of sympathetic activation with this compound. Manidipine reduces pro-inflammatory cytokines secretion in human endothelial cells and macrophages. Manidipine, unlike other third-generation dihydropyridine derived drugs, blocks T-type calcium channels present in the efferent glomerular arterioles, reducing intraglomerular pressure and microalbuminuria.

Product name	Manidipine HCl
Appearance	white Powder
Specification	99%
Shelf life	2 years when properly stored

Function and Application

Manidipine dihydrochloride is a dihydropyridine compound and calcium channel protein inhibitor and antagonist. Manidipine is described to block T-type Ca2+ channels specifically and is also described to have a high selectivity for the vasculature,presenting negligible cardiodepression as compared to other Ca2+ channel antagonists. Manidipine is also described to not significantly affect norepinephrine levels, suggesting a lack of sympathetic activation with this compound.