Doxorubicin Hydrochloride Powder CAS 25316-40-9 Doxorubicin HCl Powder

• Customization: Available
• Powder: Yes
• Customized: Customized
• Certification: GMP, ISO 9001, USP
• Suitable for: Adult
• State: Powder
• Purity: >99%
• Sample: Available
• OEM: Available
• MOQ: 1kg
• CAS: 25316-40-9
• Keyword: Doxorubicin Hydrochloride
• Keyword 1: Doxorubicin HCl
• Transport Package: 1kg Foil Bag /25kg Drum
• Specification: 99%
• Trademark: /
• Origin: China
• Production Capacity: 20000

Product Description

Product Description

Description

Doxorubicin Hydrochloride is the hydrochloride salt of doxorubicin, an anthracycline antibiotic with antineoplastic activity.   Doxorubicin, isolated from the bacterium Streptomyces peucetius var. caesius, is the hydroxylated congener of daunorubicin.   Doxorubicin intercalates between base pairs in the DNA helix, thereby preventing DNA replication and ultimately inhibiting protein synthesis.   Additionally, doxorubicin inhibits topoisomerase II which results in an increased and stabilized cleavable enzyme-DNA linked complex during DNA replication and subsequently prevents the ligation of the nucleotide strand after double-strand breakage.   Doxorubicin also forms oxygen free radicals resulting in cytotoxicity secondary to lipid peroxidation of cell membrane lipids;   the formation of oxygen free radicals also contributes to the toxicity of the anthracycline antibiotics, namely the cardiac and cutaneous vascular effects.

Product name	Doxorubicin HCl
Appearance	orange Powder
Specification	99%
Shelf life	2 years when properly stored

Function

Doxorubicin is an anthracycline antitumor antibiotic that inhibits DNA topoisomerase II by inducing double-stranded DNA breaks.   By intercalating within DNA, doxorubicin inhibits nucleic acid synthesis and induces apoptosis by inducing the accumulation of the p53 tumor suppressor protein.
Application
Doxorubicin hydrochloride is a chemotherapy medication used to treat cancer.   This includes breast cancer, bladder cancer, Kaposi's sarcoma, lymphoma, and acute lymphocytic leukemia.   It is often used together with other chemotherapy agents.