| Customization: | Available |
|---|---|
| Powder: | Yes |
| Customized: | Customized |
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| Product Name | 5-Fluorouracil |
| Appearance | White Powder |
| CAS NO. | 51-21-8 |
| MF | C4H3FN2O2 |
| Storage | Keep in a cool, dry, dark location |
5-Fluorouracil is a pyrimidine analog and a derivative of uracil, where the hydrogen atom at the 5-position of the pyrimidine ring is replaced by atom. It is a key component in the development of certain anticancer and antiviral medications.
Anticancer Therapy: 5-Fluorouracil is widely used in the treatment of various cancers, particularly solid tumors such as those of the colon, rectum, and breast. It acts by inhibiting thymidylate synthase, an enzyme essential for DNA synthesis, thereby disrupting cell division and proliferation.
Combination Therapy: It is often administered in combination with other chemotherapeutic agents to enhance its efficacy and reduce the risk of resistance development.
Topical Applications: In dermatology, 5-Fluorouracil creams are used to treat certain skin conditions, such as actinic keratosis, by promoting the shedding of abnormal cells.
DNA and RNA Synthesis Inhibition: By mimicking uracil, 5-Fluorouracil incorporates into both DNA and RNA during replication, leading to the formation of defective nucleic acids that trigger cell death.
Cell Cycle Arrest: It specifically targets the S phase of the cell cycle, where DNA replication occurs, causing cell cycle arrest and subsequent apoptosis (programmed cell death).
Antimetabolite Activity: As an antimetabolite, 5-Fluorouracil disrupts metabolic pathways essential for cell growth and survival, making it an effective therapeutic agent against rapidly dividing cells, such as those found in cancerous tumors.
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