Antidiarrheal Loperamide HCl Powder CAS 34552-83-5 Loperamide Hydrochloride

• Customization: Available
• Powder: Yes
• Customized: Customized
• Model NO.: A25
• Certification: GMP, HSE, ISO 9001, USP, BP
• Suitable for: Adult
• State: Powder
• Purity: >99%
• Name: Loperamide Hydrochloride
• Appearance: White Powder
• Assay: 99%
• CAS: 34552-83-5
• OEM: Available
• Sample: Available
• Suitable: Adult
• Function: Antidiarrheal
• Transport Package: Foil Bag
• Specification: 99
• Trademark: /
• Origin: China
• Production Capacity: 10000 Kgs Per Month

Product Description

Product Name	Loperamide
CAS No.	53179-11-6
MF	C29H33ClN2O2
MW	477.03752
Appearance and shape	White to off white crystalline powder

Loperamide hydrochloride is a white or off white crystalline powder. Loperamide hydrochloride (Imodium) structurally resembles both haloperidol. In equal doses, loperamide protects against diarrhea. It reduces the daily fecal volume and decreases intestinal fluid and electrolyte loss. Loperamide produces rapid and sustained inhibition of the peristaltic reflex through depression of longitudinal and circular muscle activity.The drug also possesses antisecretory activity, presumably through an effect on intestinal opioid receptors.

 

1. Diarrhea Treatment: Used primarily to treat acute and chronic diarrhea by slowing down intestinal motility.
2. Traveler's Diarrhea: Effective in managing diarrhea associated with travel, often caused by bacterial infections.
3. Irritable Bowel Syndrome (IBS): Can be prescribed for diarrhea-predominant IBS to reduce frequency and urgency of bowel movements.
4. Postoperative Recovery: Aids in post-surgical recovery by controlling diarrhea that may result from anesthesia or surgery.

1. Antidiarrheal Action: Works by increasing the transit time of intestinal contents, allowing for more water and electrolytes to be reabsorbed into the body, thus reducing the volume and frequency of bowel movements.
2. Mucosal Protection: Enhances the mucus production in the intestinal lining, providing a protective barrier against irritants and aiding in fluid absorption.
3. Opioid Receptor Activation: Acts as an agonist on mu-opioid receptors in the gut, specifically targeting the intestines, minimizing its central nervous system effects compared to other opioids.
4. Selective Activity: Primarily affects the intestinal smooth muscle, limiting its systemic side effects, making it safer for long-term use in managing chronic diarrhea.