Factory 99% Trimethoprim Powder CAS 738-70-5 Chemical Intermediate Trimethoprim

• Customization: Available
• Powder: Yes
• Customized: Customized
• Model NO.: A758
• Certification: GMP, HSE, ISO 9001, USP, BP
• Suitable for: Elderly, Children, Adult
• State: Powder
• Purity: >99%
• Name: Trimethoprim
• CAS: 738-70-5
• Appearance: White Powder
• Assay: 99%
• OEM: Available
• Sample: Available
• Suitable: Adult
• MOQ: 1g
• Function: Chemical Intermediate
• Transport Package: Foil Bag
• Specification: 99
• Trademark: /
• Origin: China
• Production Capacity: 10000 Kgs Per Month

Product Description

 

Product Name	Trimethoprim
Appearance	White Powder
CAS NO.	738-70-5
Storage	Keep in a cool, dry, dark location

 

Trimethoprim, also known as TMP, is an organic compound with the chemical formula C14H18N4O3. It is classified as a broad-spectrum bacteriostatic antibiotic and an orally active dihydrofolate reductase (DHFR) inhibitor. Trimethoprim exists as a white to light yellow crystalline powder, which is odorless but has a bitter taste. It is slightly soluble , sparingly soluble in ethanol , practically insoluble in water, but freely soluble in glacial acetic acid.

 

1. Antibiotic Therapy: Trimethoprim is commonly used in antibiotic therapy for the treatment of various bacterial infections, including respiratory, urinary tract, and intestinal infections.
2. Combination Therapy: It is often combined with sulfonamides or other antibiotics to enhance its antibacterial activity and broaden its spectrum of action against both Gram-positive and Gram-negative bacteria.
3. Scientific Research: Trimethoprim is also used in scientific research to study its antibacterial mechanisms, interactions with other drugs, and potential new therapeutic applications.

1. DHFR Inhibition: The primary function of Trimethoprim is to inhibit the activity of dihydrofolate reductase (DHFR), an enzyme essential for bacterial folate metabolism. By inhibiting DHFR, Trimethoprim disrupts the synthesis of tetrahydrofolate, which is required for bacterial growth and division.
2. Bacteriostatic Effect: As a bacteriostatic antibiotic, Trimethoprim inhibits the growth of bacteria but does not necessarily kill them. This makes it useful in combination therapy where it can synergize with other antibiotics to enhance their bactericidal effect.
3. Broad-Spectrum Activity: Trimethoprim has activity against a wide range of bacteria, including both Gram-positive and Gram-negative organisms. This broad-spectrum activity makes it a valuable antibiotic in the treatment of various infections caused by susceptible bacteria.