Factory 99% Obeticholic Acid Powder CAS 459789-99-2 Chemical Intermediate Obeticholic Acid

• Customization: Available
• Powder: Yes
• Customized: Customized
• Model NO.: A861
• Certification: GMP, HSE, ISO 9001, USP, BP
• Suitable for: Elderly, Children, Adult
• State: Powder
• Purity: >99%
• Name: Obeticholic Acid
• CAS: 459789-99-2
• Appearance: White Powder
• Assay: 99%
• OEM: Available
• Sample: Available
• Suitable: Adult
• MOQ: 1g
• Function: Chemical Intermediate
• Transport Package: Foil Bag
• Specification: 99
• Trademark: /
• Origin: China
• Production Capacity: 10000 Kgs Per Month

Product Description

 

Product Name	Obeticholic Acid
Appearance	White Powder
CAS NO.	459789-99-2
Storage	Keep in a cool, dry, dark location

 

Obeticholic Acid, also known as 6-Ethylchenodeoxycholic acid or OCA, is a novel derivative of Chenodeoxycholic Acid (CDCA) found in human primary bile acids. It serves as a natural ligand for the Farnesoid X Receptor (FXR), making it a potent FXR agonist.

 

1. Treatment of Primary Biliary Cholangitis (PBC): Obeticholic Acid is approved by the FDA for the treatment of PBC, particularly in patients who are intolerant or have an inadequate response to Ursodeoxycholic Acid (UDCA). It significantly improves biochemical markers, delays disease progression, and enhances survival rates.
2. Therapy for Non-alcoholic Steatohepatitis (NASH): This compound has demonstrated efficacy in treating NASH, reducing liver inflammation, and improving histological changes in liver tissue. The FDA has granted it Breakthrough Therapy designation for this indication.
3. Research and Development: Due to its unique mechanism of action in regulating bile acid metabolism, Obeticholic Acid is under continuous research and development for potential new therapeutic applications in liver diseases and beyond.

1. Regulation of Bile Acid Metabolism: By interacting with the FXR receptor, Obeticholic Acid regulates the synthesis and excretion of bile acids in the liver, thereby maintaining bile acid homeostasis.
2. Protection of Liver Function: It induces hepatocytes to synthesize and secrete more bile acids while inhibiting the synthesis of triglycerides, which protects the liver from inflammation, necrosis, and fibrosis.
3. Improvement of Biochemical Markers: In patients with PBC, Obeticholic Acid has been shown to improve biochemical markers such as alkaline phosphatase (ALP) and alanine aminotransferase (ALT) levels, indicating its therapeutic benefit in this condition.