High Quality Veterinary Raw Material Pralidoxime Chloride Powder CAS 51-15-0 Pralidoxime Chloride

• Customization: Available
• Powder: Yes
• Customized: Customized
• Model NO.: API
• Certification: GMP, ISO 9001
• Suitable for: All
• State: Liquid
• Purity: >99%
• Keyword: Pralidoxime Chloride
• CAS: 51-15-0
• Mf: C7h9cln2o
• Sample: Available
• MOQ: 1kg
• Test Method: HPLC
• Transport Package: Aluminum Foil Bag/Paper Drum
• Specification: 99%
• Trademark: xinlu
• Origin: China
• Production Capacity: 100kg

Product Description

Pralidoxime chloride is a synthetic compound. Its chemical structure contains a ring with specific functional groups. This structure is crucial for its interaction with the target molecules in the body. It is an oxime derivative, which gives it the ability to react with phosphorylated enzymes, a key aspect of its mode of action.

 

 

Product Name	High Quality Veterinary Raw Material Pralidoxime Chloride Powder CAS 51-15-0 Pralidoxime Chloride
Appearance	White powder
cas	51-15-0
Keywords	Pralidoxime Chloride;Pralidoxime Chloride Powder;Pralidoxime Chloride CAS 51-15-0
Shelf Life	24 months when properly stored
Storage	Keep in a cool, dry, dark location

1. Reactivation of Cholinesterase:Pralidoxime chloride's main function is to reactivate acetylcholinesterase. Organophosphate compounds inhibit this enzyme by phosphorylating it. Pralidoxime chloride binds to the phosphorylated enzyme and removes the phosphate group, thus restoring the enzyme's activity. This is essential as acetylcholinesterase is responsible for breaking down acetylcholine, a neurotransmitter.
2. Correction of Neurotransmitter Imbalance:By reactivating acetylcholinesterase, pralidoxime chloride helps correct the neurotransmitter imbalance caused by organophosphate poisoning. In poisoning cases, acetylcholine accumulates due to enzyme inhibition, leading to over - stimulation of cholinergic receptors. Pralidoxime chloride's action reduces this excessive acetylcholine, alleviating symptoms such as muscle twitching, excessive sweating, and respiratory distress.
3. Specificity to Organophosphate Poisoning:It is highly specific for treating organophosphate poisoning. It has no significant effect on other types of toxic exposures. This specificity is due to its unique chemical structure that can only interact with the phosphorylated form of acetylcholinesterase, which is a characteristic result of organophosphate exposure.

1. Medical Emergency Use:Pralidoxime chloride is primarily used in emergency medicine. In cases of suspected organophosphate poisoning, it is administered as soon as possible. This could be due to accidental exposure to agricultural pesticides or in cases of chemical warfare - related nerve agent exposure. Early administration can improve the prognosis and reduce the severity of symptoms.
2. Combination Therapy:It is often used in combination with atropine. Atropine addresses the muscarinic symptoms of organophosphate poisoning, such as excessive salivation and bronchospasm. Pralidoxime chloride, on the other hand, focuses on reactivating the enzyme. Together, they provide a more comprehensive treatment approach for patients suffering from organophosphate toxicity.
3. Dose and Administration:The dose of pralidoxime chloride varies depending on the severity of poisoning and the patient's age and weight. For adults, the initial dose is typically 1 - 2 grams, administered either intravenously or intramuscularly. In children, the dose is calculated based on body weight. The route of administration depends on the patient's condition, with intravenous being preferred in severe cases for rapid onset of action.

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