Factory 99% Topotecan HCl Powder CAS 119413-54-6 Anti-Tumor Topotecan HCl

• Customization: Available
• Powder: Yes
• Customized: Customized
• Model NO.: A91
• Certification: GMP, HSE, ISO 9001, USP, BP
• Suitable for: Adult
• State: Powder
• Purity: >99%
• Name: Topotecan HCl
• Appearance: White Powder
• Assay: 99%
• CAS: 119413-54-6
• OEM: Available
• Sample: Available
• Suitable: Adult
• Function: Anti-Tumor
• MOQ: 10g
• Transport Package: Foil Bag
• Specification: 99
• Trademark: /
• Origin: China
• Production Capacity: 10000 Kgs Per Month

Product Description

Product Name	Topotecan Hydrochloride
Appearance	White Powder
CAS NO.	119413-54-6
Molecular Formula	C23H24ClN3O5
Storage	Keep in a cool, dry, dark location

 

_{Topotecan hydrochloride is a water-soluble derivative of camptothecin, which is the form of hydrochloride of topotecan. It is successfully developed by the SmithKline Beecham US company, and approved by the FDA in the United States in 1996. Its trade name is Hycamtin. It is applied in the treatment of ovarian cancer (OVC) as the second-line therapy.} 

 

1. Cancer Treatment: Topotecan Hydrochloride is primarily used in the treatment of ovarian cancer, particularly in patients who have relapsed after initial chemotherapy.
2. Cervical Cancer: It is also indicated for the treatment of certain types of cervical cancer, offering an alternative therapeutic option for patients with this malignancy.
3. Combination Therapy: Topotecan Hydrochloride may be used in combination with other chemotherapeutic agents to enhance treatment outcomes in select cancer cases.

1. DNA Topoisomerase I Inhibition: Topotecan Hydrochloride functions by inhibiting the activity of DNA topoisomerase I, an enzyme involved in DNA replication and repair.
2. Induction of Cell Death: Inhibition of topoisomerase I leads to DNA damage, which triggers the apoptotic (programmed cell death) pathway in cancer cells, ultimately resulting in their destruction.
3. Selective Cytotoxicity: Topotecan Hydrochloride exhibits selective cytotoxicity towards cancer cells, sparing normal cells to a greater extent, making it an effective therapeutic agent in the fight against cancer.