| Customization: | Available |
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| Powder: | Yes |
| Customized: | Customized |
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| Product Name | Yohimbine HCL |
| Appearance | White Powder |
| CAS NO. | 65-19-0 |
| Molecular Formula | C21H27ClN2O3 |
| Storage | Keep in a cool, dry, dark location |
Yohimbine HCL is the name of an evergreen tree found in parts of central and western Africa. The bark of yohimbe contains a chemical called yohimbine, which is used to make medicine. Yohimbine hydrochloride (Aphrodyne, Yocon) is a form of yohimbine that is a prescription drug in the US.
Yohimbe supplements often list yohimbe bark extract or yohimbine as the active ingredient.
Medicinal Use: It is primarily used in the treatment of male sexual dysfunction, specifically to address erectile dysfunction (ED) by stimulating the sympathetic nervous system and blocking alpha-2 adrenergic receptors, enhancing blood flow to the penis.
Research Purposes: In scientific research, yohimbine hydrochloride serves as a pharmacological tool to study the role of adrenergic receptors in various physiological processes, including neurotransmission, cardiovascular function, and more.
Supplement Industry: Available as a dietary supplement, it is marketed for weight loss, athletic performance enhancement, and mood elevation, though these claims are not universally supported by robust scientific evidence.
Alpha-2 Adrenergic Receptor Antagonist: Yohimbine competitively binds to and blocks alpha-2 adrenergic receptors, which are involved in regulating vasoconstriction, neurotransmitter release, and hormone secretion. This blockage leads to increased blood flow and, in the context of sexual dysfunction, can facilitate erections.
Stimulation of Norepinephrine Release: By blocking alpha-2 receptors, yohimbine indirectly stimulates the release of norepinephrine (a stress hormone and neurotransmitter) from sympathetic nerve endings, further contributing to its effects on blood flow and arousal.
Potential Cognitive and Mood Enhancement: Although not a primary function, some anecdotal evidence and preliminary studies suggest yohimbine may have a mild stimulatory effect on cognitive performance and mood elevation, possibly due to its interaction with the adrenergic system and neurotransmitter release. However, these effects are not well-established and require further investigation.
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