Factory 99% Pyrimethamine Powder CAS 58-14-0 Antimalarial Pyrimethamine

• Customization: Available
• Powder: Yes
• Customized: Customized
• Model NO.: A519
• Suitable for: Elderly, Children, Adult
• State: Powder
• Purity: >99%
• Name: Pyrimethamine
• CAS: 58-14-0
• Appearance: White Powder
• Assay: 99%
• OEM: Available
• Sample: Available
• Suitable: Adult
• MOQ: 10g
• Function: Antimalarial
• Transport Package: Foil Bag
• Specification: 99
• Trademark: /
• Origin: China
• Production Capacity: 10000 Kgs Per Month

Product Description

Product Name	Pyrimethamine
Appearance	White Powder
CAS NO.	58-14-0
Molecular Formula	C10H12N4S
Storage	Keep in a cool, dry, dark location

 

Pyrimethamine is an antimalarial drug that belongs to the dihydrofolate reductase inhibitors class. It is specifically used to treat and prevent malaria caused by certain strains of Plasmodium parasites.

 

1. Malaria Treatment: Pyrimethamine is commonly administered in combination with other drugs, such as sulfadoxine (as in the combination therapy known as Fansidar), to treat uncomplicated malaria.
2. Prophylaxis: It can also be used as a prophylactic agent to prevent malaria in individuals traveling to endemic areas.
3. Toxoplasmosis: In some cases, pyrimethamine is prescribed in combination with sulfonamides for the treatment of toxoplasmosis, a parasitic infection that can affect various organs.

1. Inhibition of Dihydrofolate Reductase: Pyrimethamine inhibits the enzyme dihydrofolate reductase, which is essential for the synthesis of purine nucleotides and thymidylate, thereby disrupting the parasite's DNA replication and RNA synthesis.
2. Selective Toxicity: It exhibits selective toxicity towards Plasmodium parasites, making it an effective target for malaria treatment while minimizing harm to the host cells.
3. Synergistic Effects: When combined with sulfonamides, pyrimethamine enhances the overall antimalarial activity by blocking different pathways in the parasite's folate metabolism.