Factory 99% Ifosfamide Powder CAS 3778-73-2 Chemical Intermediate Ifosfamide

• Customization: Available
• Powder: Yes
• Customized: Customized
• Model NO.: A998
• Certification: GMP, HSE, ISO 9001, USP, BP
• Suitable for: Elderly, Children, Adult
• State: Powder
• Purity: >99%
• Name: Ifosfamide
• CAS: 3778-73-2
• Appearance: White Powder
• Assay: 99%
• OEM: Available
• Sample: Available
• Suitable: Adult
• MOQ: 1g
• Function: Chemical Intermediate
• Transport Package: Foil Bag
• Specification: 99
• Trademark: /
• Origin: China
• Production Capacity: 10000 Kgs Per Month

Product Description

 

Product Name	Ifosfamide
Appearance	White Powder
CAS NO.	3778-73-2
Storage	Keep in a cool, dry, dark location

 

Ifosfamide is a nitrogen mustard alkylating agent used as a chemotherapeutic drug. It is a synthetic analog of cyclophosphamide and functions by cross-linking DNA, thereby inhibiting DNA synthesis and causing cell death in rapidly dividing cancer cells.Ifosfamide's utility is constrained by side effects such as hemorrhagic cystitis (mitigated by mesna) and myelosuppression, necessitating careful monitoring during administration.

 

1. Cancer Treatment: Approved for treating various malignancies, including testicular cancer, sarcomas, lymphomas, and ovarian cancer.
2. Combination Therapy: Often used in multi-drug regimens (e.g., with etoposide, doxorubicin) to enhance efficacy.
3. Relapsed/Refractory Cases: Administered in patients who have not responded to or relapsed after initial chemotherapy.

1. DNA Alkylation: Ifosfamide is metabolized in the liver by cytochrome P450 enzymes into active alkylating species that bind to DNA, causing strand breaks and apoptosis.
2. Cytotoxicity: Targets rapidly dividing cells, making it effective against cancers but also causing dose-limiting toxicities in normal tissues.
3. Immune Modulation: Induces immunogenic cell death, potentially enhancing anti-tumor immune responses.