| Customization: | Available |
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| Powder: | Yes |
| Customized: | Customized |
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| Product Name | Celecoxib |
| CAS NO. | 169590-42-5 |
| Purity | 99% |
| Density | 1.43 |
| Appearance and shape | White powder |
Celecoxib is a selective Cox-2(cyclooxygenase-2) inhibitor (IC50 of 40 nM). Celecoxib shows low sensitivity against Cox-1 (IC50 of 15 μM). Celecoxib shows an anti-proliferative effect on nasopharyngeal carcinoma (NPC) cell lines including HNE1 (IC50of 32.86 μM) and CNE1-LMP1 (IC50 of 61.31 μM).
Osteoarthritis and Rheumatoid Arthritis: Celecoxib is primarily used for the relief of pain, inflammation, and stiffness caused by osteoarthritis and rheumatoid arthritis.
Acute Pain Management: It can also be prescribed for the short-term management of acute pain in adults, such as post-operative pain or pain from injuries.
Dysmenorrhea (Painful Menstrual Cramps): Celecoxib has been found to be effective in reducing the pain and discomfort associated with menstrual cramps.
Selective COX-2 Inhibitor: Celecoxib selectively inhibits the cyclooxygenase-2 (COX-2) enzyme, which is responsible for the production of prostaglandins involved in pain, inflammation, and fever. This selectivity reduces the risk of gastrointestinal side effects compared to non-selective NSAIDs.
Anti-Inflammatory Action: By inhibiting COX-2, celecoxib reduces inflammation at the site of injury or disease, helping to alleviate pain and swelling.
Analgesic Effect: Its ability to inhibit prostaglandin production also contributes to its analgesic (pain-relieving) properties, allowing patients to manage their pain more effectively.
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