Chemical Intermediate Chloroquine Phosphate Powder CAS 50-63-5 Chloroquine Phosphate

• Customization: Available
• Powder: Yes
• Customized: Customized
• Model NO.: API
• Certification: GMP, ISO 9001
• Suitable for: All
• State: Solid
• Purity: >99%
• Keyword: Ranitidine
• Sample: Available
• MOQ: 1kg
• Mf: C18h32cln3o8p2
• CAS: 50-63-5
• Test Method: HPLC
• Transport Package: Aluminum Foil Bag/Paper Drum
• Specification: 99%
• Trademark: xinlu
• Origin: China
• Production Capacity: 100kg

Product Description

Chloroquine Phosphate is the phosphate salt of chloroquine, a compound with antimalarial and anti-inflammatory properties. Chloroquine is the most widely used drug against malaria, except for those cases caused by chloroquine resistant Plasmodium falciparum. Although the mechanism of action is not fully understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite. Chloroquine may also interfere with the biosynthesis of nucleic acids.

 

Product Name	Chloroquine Phosphate
CAS No.	50-63-5
MF	C18H32ClN3O8P2
MW	515.86300
Appearance and shape	White Powder

1. Parasite Inhibition: By accumulating within the acidic digestive vacuole of malaria parasites, chloroquine phosphate disrupts essential heme polymerization, leading to the death of the parasite.

2. Lysosomal Dysfunction: In cellular contexts, it acts as a weak base that raises the pH of acidic organelles like lysosomes, inhibiting their proteolytic enzymes and disrupting autophagy-a cellular degradation process crucial for maintaining homeostasis.

3. Antiproliferative Activity: In certain cancer cell lines, chloroquine phosphate has demonstrated antiproliferative effects by inhibiting autophagy, which cancer cells often rely on for survival under stress conditions.

4. Immunomodulation: Through its impact on immune cell signaling and autophagy, chloroquine phosphate can modulate immune responses, though the specific mechanisms and applications in this regard are still being elucidated.

1. Malaria Treatment: It is primarily used as an antimalarial drug to treat and prevent certain types of malaria caused by sensitive strains of the parasite Plasmodium.

2. Amebiasis Therapy: In some regions, it may also be employed in the treatment of extraintestinal amebiasis (a parasitic infection caused by Entamoeba histolytica).

3. Immunomodulatory Effects: In some experimental settings, chloroquine phosphate has shown immunomodulatory properties, which are being explored for potential use in autoimmune diseases and cancer therapies, though these applications are still under investigation.

4. Laboratory Research: It serves as a vital tool in research laboratories for studying cellular processes, including autophagy inhibition, due to its ability to disrupt lysosomal function.

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