| Customization: | Available |
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| Powder: | Yes |
| Customized: | Customized |
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| Product Name | Rebamipide |
| Appearance | White powder |
| CAS No. | 90098-04-7 |
| MF | C19H15ClN2O4 |
| MW | 370.7864 |
Rebamipide an amino acid derivative of 2-(1H)-quinolinone, is used for mucosal protection, healing of gastroduodenal ulcers, and treatment of gastritis. It works by enhancing mucosal defense, scavenging free radicals, and temporarily activating genes encoding cyclooxygenase-2.
Gastrointestinal Treatment: Rebamipide (also known as Rebamipidc, Rebamlplde, or Ruibapaite) is primarily used in the treatment of gastrointestinal disorders, particularly in the management of gastric ulcers and gastritis. It is an effective medication for improving and healing gastric mucosal lesions.
Prevention and Healing of Gastric Ulcers: The drug has been shown to prevent the occurrence of gastric ulcers and accelerate their healing process by increasing gastric mucosal blood flow and prostaglandin E2 synthesis. It also promotes the regeneration of gastric mucosal cells.
Adjunct Therapy: Rebamipide is often prescribed as an adjunct to other medications in the treatment of chronic gastritis, particularly during acute exacerbations characterized by mucosal erosions, bleeding, congestion, and edema.
Mucosal Protective Effects: Rebamipide exerts its protective effects on the gastric mucosa by increasing mucosal blood flow and prostaglandin levels, which enhances the defense mechanisms of the mucosa against injurious agents.
Antioxidant and Anti-inflammatory Actions: The drug possesses antioxidant properties, scavenging reactive oxygen species and hydroxyl radicals, thereby reducing oxidative stress and inflammation in the gastric mucosa. This helps in the healing of gastric ulcers and alleviates associated symptoms.
Inhibition of Harmful Factors: Rebamipide has been found to inhibit the infiltration of inflammatory cells into the gastric mucosa and suppress the production of harmful cytokines by Helicobacter pylori (Hp), an important bacterial factor in the development of gastric ulcers. Additionally, it can prevent Hp adhesion to gastric epithelial cells, further reducing the risk of mucosal damage.
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