Customization: | Available |
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Powder: | Yes |
Customized: | Customized |
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Product name | Pramipexole |
Cas number | 191217-81-9 |
Apperance | White powder |
MF | C10H20ClN3OS |
MW | 302.26 |
Parkinson's Disease Treatment: Pramipexole is primarily used as a dopamine agonist in the management of the signs and symptoms of Parkinson's disease, including rigidity, bradykinesia, and resting tremor.
Symptomatic Relief: It helps alleviate motor fluctuations and dyskinesias associated with long-term levodopa therapy, offering an alternative or adjunctive therapy option.
Restorative Sleep & Non-motor Symptoms: Pramipexole may also be prescribed to address non-motor symptoms such as sleep disturbances and depression, though its efficacy for these indications is less well established.
Dopamine Receptor Stimulation: Pramipexole selectively stimulates postsynaptic dopamine D2 and D3 receptors in the striatum, the region of the brain primarily affected in Parkinson's disease.
Neurotransmitter Modulation: By enhancing dopamine signaling, it restores the imbalance caused by the loss of dopaminergic neurons, which is a hallmark of Parkinson's pathology.
Improving Motor Control: The increased dopamine levels facilitate smoother muscle movements, reducing stiffness, slowing of movement (bradykinesia), and involuntary movements (dyskinesias), thereby improving overall motor function and quality of life for patients.