Factory 99% Crisaborole Powder CAS 906673-24-3 Chemical Intermediate Crisaborole

• Customization: Available
• Powder: Yes
• Customized: Customized
• Model NO.: A995
• Certification: GMP, HSE, ISO 9001, USP, BP
• Suitable for: Elderly, Children, Adult
• State: Powder
• Purity: >99%
• Name: Crisaborole
• CAS: 906673-24-3
• Appearance: White Powder
• Assay: 99%
• OEM: Available
• Sample: Available
• Suitable: Adult
• MOQ: 1g
• Function: Chemical Intermediate
• Transport Package: Foil Bag
• Specification: 99
• Trademark: /
• Origin: China
• Production Capacity: 10000 Kgs Per Month

Product Description

 

Product Name	Crisaborole
Appearance	White Powder
CAS NO.	906673-24-3
Storage	Keep in a cool, dry, dark location

 

Crisaborole (C14H10BNO3) is a non-steroidal, topical phosphodiesterase-4 (PDE4) inhibitor designed to treat inflammatory skin conditions. It selectively inhibits PDE4, an enzyme that degrades cyclic adenosine monophosphate (cAMP), thereby increasing intracellular cAMP levels. This leads to downregulation of pro-inflammatory cytokines and mediators, reducing inflammation and pruritus.

 

1. Atopic Dermatitis (AD): Approved in the US (2016) and EU (2020) for mild-to-moderate AD in patients aged ≥3 months, offering a steroid-free alternative for sensitive skin.
2. Topical Therapy: Formulated as a 2% ointment (Eucrisa®) for localized application, avoiding systemic side effects associated with oral immunosuppressants.
3. Pediatric Use: Demonstrated safety and efficacy in children as young as 3 months, addressing a critical unmet need in pediatric dermatology.

1. Anti-inflammatory Action: Inhibits PDE4 to elevate cAMP, suppressing TNF-α, IL-2, and IL-23 release from immune cells, thereby reducing erythema, edema, and lichenification.
2. Pruritus Relief: Blocks itch-signaling pathways via modulation of neurogenic inflammation, improving patient quality of life.
3. Skin Barrier Restoration: Enhances epidermal differentiation and lipid synthesis, potentially mitigating transepidermal water loss and improving skin resilience.