Chemical Intermediate Mitomycin C Powder CAS 51333-22-3 Mitomycin

• Customization: Available
• Powder: Yes
• Customized: Customized
• Model NO.: API
• Certification: GMP, ISO 9001
• State: Solid
• Purity: >99%
• Keyword: Mitomycin
• CAS: 51333-22-3
• Mf: C15h18n4o5
• Sample: Available
• MOQ: 1kg
• Test Method: HPLC
• Transport Package: Aluminum Foil Bag/Paper Drum
• Specification: 99%
• Trademark: xinlu
• Origin: China
• Production Capacity: 100kg

Product Description

 

What is mitomycin?

Mitomycin C is extracted from Streptomyces bacteria (bacteria) out of a broad-spectrum antitumor antibiotics, genetic toxicity and tumor resistance, is widely recognized inhibitors of DNA damage, have anti-cancer effect to many kinds of cancer, after activation, can play a role of DNA alkylating agent, action principle is to make the cell's DNA depolymerization, selective inhibit DNA, RNA and protein synthesis, cell and inhibiting tumor cell division.

 

 

 

 

Appearance	Blue powder
Molecular formula	C15H18N4O5
Molecular Weight	334.33
Keywords	Mitomycin;Mitomycin Powder;Mitomycin CAS 51333-22-3
Shelf Life	24 months when properly stored
Storage	Keep in a cool, dry, dark location

1. Mitomycin C (MMC), an antineoplastic antibiotic derived from Streptomyces caespitosus or Streptomyces lavendulae, is a cell cycle-specific alkylating agent, inhibits DNA synthesis through covalent mitomycin C-DNA adduct with EC50 values of 0.14μM in PC3 cells. Therefore, it was served as a chemotherapeutic agent that has demonstrated its antitumor activity and has been used widely in treatment of various cancers.
    
2. Although it is active against a wide variety of tumors, newer agents have largely replaced MMC except in anal cancer; outside of the United States, MMC is infrequently used for treatment of advanced non-small cell lung cancer (NSCLC), and breast cancer.

1. It is a cell division inhibitors, nucleic acid inhibitors and phage inducer; an anti-tumor drugs in clinical use.
2. This drug has a broad anti-tumor spectrum, and effective for gastric cancer, breast cancer. It has a certain effect on lung cancer, liver cancer, malignant lymphoma, Hodgkin's disease, reticular cell sarcoma, uterine cancer, leukemia, intestinal cancer and pancreatic cancer, but with a short remission. Combination with urokinase can improve the efficacy. The goods exert its function quickly, but the number of operators is not high, and it has a high toxicity. The goods and bleomycin as well as its derivatives --doxorubicin are anti-cancer drugs of antibiotic which can disrupt DNA. It can depolymerize DNA in the cell, inhibit DNA replication in proliferating cell. The LD50 of intravenous injection of mice is 5ml It acts as an anticancer drugs, commonly used in the treatment of digestive system cancers.

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