Factory 99% Probenecid Powder CAS 57-66-9 Chemical Intermediate Probenecid

• Customization: Available
• Powder: Yes
• Customized: Customized
• Model NO.: A915
• Certification: GMP, HSE, ISO 9001, USP, BP
• Suitable for: Elderly, Children, Adult
• State: Powder
• Purity: >99%
• Name: Probenecid
• CAS: 57-66-9
• Appearance: White Powder
• Assay: 99%
• OEM: Available
• Sample: Available
• Suitable: Adult
• MOQ: 1g
• Function: Chemical Intermediate
• Transport Package: Foil Bag
• Specification: 99
• Trademark: /
• Origin: China
• Production Capacity: 10000 Kgs Per Month

Product Description

 

Product Name	Probenecid
Appearance	White Powder
CAS NO.	57-66-9
Storage	Keep in a cool, dry, dark location

 

Probenecid, also known as glutaryl sulfonamide or 4-(dipropylsulfamoyl)benzoic acid, is an organic compound with multiple pharmacological applications.

 

1. Antigout Medication: Probenecid is primarily used in the treatment of gout and hyperuricemia. By inhibiting the reabsorption of uric acid in the proximal tubules of the kidneys, it increases the excretion of uric acid in the urine, thereby lowering blood uric acid levels and reducing the risk of gout flares.

2. Antibiotic Adjuvant: Probenecid is also used as an adjuvant to enhance the antibacterial effects of certain antibiotics, such as penicillin and cephalosporins. By inhibiting the renal tubular secretion of these antibiotics, probenecid increases their plasma concentrations and prolongs their duration of action.

3. Research Tool: Due to its ability to inhibit various transporters, probenecid is also used as a research tool in the study of drug transport and pharmacokinetics.

1. Uric Acid Excretion: The primary function of probenecid is to promote the excretion of uric acid from the body. By inhibiting the urate/anion exchanger (URAT1) in the proximal tubules of the kidneys, it prevents the reabsorption of uric acid into the bloodstream, leading to increased urinary excretion.

2. Antibiotic Potentiation: By inhibiting the renal tubular secretion of antibiotics, probenecid increases their plasma concentrations and prolongs their duration of action. This enhances the antibacterial effects of these drugs, allowing for lower doses or less frequent administration.

3. Transporter Inhibition: Probenecid is a potent inhibitor of various organic anion transporters (OATs) and multidrug resistance-associated proteins (MRPs). This property makes it a useful tool in the study of drug transport and pharmacokinetics, as well as in the development of new therapeutic strategies targeting these transporters.