Customization: | Available |
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Certification: | RoHS, BRC, ISO, FDA, HACCP |
Assay Method: | HPLC-MS, GPC, HPLC, UV |
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Product Name | Phlorizin |
Appearance | White Powder |
CAS NO. | 60-81-1 |
Storage | Keep in a cool, dry, dark location |
Phlorizin, also known as Phloridzin, is a toxic 2'-glucoside of phloretin belonging to the class of flavonoids known as dihydrochalcones.
Medicinal Research: Phlorizin is studied extensively in medicinal research due to its potential therapeutic benefits. It has been investigated for its anti-aging properties, as well as its ability to regulate blood glucose levels.
Food Additive: Phlorizin has been approved as a food additive and is found naturally in apples, particularly in their roots, stems, leaves, and fruits. It is used as a natural sweetener and flavor enhancer in some food products.
Nutritional Supplements: Due to its antioxidant and potential health-promoting properties, phlorizin is incorporated into nutritional supplements aimed at supporting overall health and wellness.
SGLT Inhibitor: Phlorizin acts as a non-selective inhibitor of sodium-glucose cotransporters (SGLT1 and SGLT2), which are responsible for glucose reabsorption in the kidney. This inhibition can lead to increased glucose excretion in the urine, making it a potential therapeutic target for the management of diabetes.
Antioxidant: Phlorizin exhibits antioxidant activity, which helps to protect cells from damage caused by oxidative stress. This property contributes to its potential anti-aging and health-promoting effects.
Na+/K+-ATPase Inhibitor: Additionally, phlorizin acts as an inhibitor of the Na+/K+-ATPase enzyme, which plays a crucial role in maintaining cellular ion homeostasis. This function may have implications in various physiological processes, including neural transmission and muscle contraction.