Cosmetic Ingredient Anti-Acne Anti-Microbial 98% Lz1 Peptide Powder

• Customization: Available
• CAS No.: /
• Formula: /
• Model NO.: D116
• EINECS: /
• Type: Cosmetic Ingredient
• Appearance: Powder
• Quality: Technical
• Colour: White
• Name: Lz1 Peptide
• Assay: 98%
• OEM: Available
• Sample: Available
• Suitable: Adult
• MOQ: 1g
• Transport Package: Foil Bag
• Specification: 99
• Trademark: /
• Origin: China
• Production Capacity: 10000 Kgs Per Month

Product Description

Product Name	LZ1 Peptide
Appearance	White Powder
Storage	Keep in a cool, dry, dark location

 

1. LZ1 Peptide is an artificially designed antimicrobial peptide composed of 15 amino acids (sequence: Val-Lys-Arg-Trp-Lys-Lys-Trp-Trp-Arg-Lys-Trp-Lys-Lys-Trp-Val-NH2). With a molecular weight of 2228.77 Da and an isoelectric point of 12.05, it exhibits broad-spectrum antimicrobial activity, low hemolytic toxicity, and stability in human plasma. Its structure, rich in positively charged amino acids (e.g., lysine, arginine) and aromatic residues (tryptophan), enables electrostatic interactions with bacterial membranes, disrupting integrity and inducing cell death.

 

 

1. Antimicrobial Therapy: Used as a potential alternative to traditional antibiotics due to its efficacy against drug-resistant pathogens like Staphylococcus aureus and Propionibacterium acnes.
2. Anti-Acne Formulations: Incorporated into topical treatments to reduce inflammatory lesions by inhibiting bacterial growth and modulating cytokine secretion (e.g., TNF-α, IL-1β).
3. Antimalarial Research: Investigated for its ability to inhibit Plasmodium falciparum growth (IC50 = 3.045 μM) by targeting pyruvate kinase, offering a novel approach for malaria treatment.

1. Membrane Disruption: Binds to negatively charged bacterial membranes via electrostatic interactions, forming pores or channels that compromise membrane integrity and induce osmotic lysis.
2. Anti-Inflammatory Activity: Reduces pro-inflammatory cytokine production, alleviating inflammation in acne-prone skin and improving wound healing outcomes.
3. Immunomodulation: Enhances host defense mechanisms by promoting immune cell recruitment and regulating innate immune responses, though further studies are needed to elucidate specific pathways.