| Customization: | Available |
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| Powder: | Yes |
| Customized: | Customized |
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| Product Name | Tacrolimus |
| CAS NO. | 104987-11-3 |
| Purity | 99% |
| Density | 1.19 |
| Appearance and shape | White powder |
Tacrolimus, also known as FK506, is a fermentation product isolated from Streptomyces. It is a macrolide antibiotic and a powerful new immunosuppressant, mainly by inhibiting interleukin-2 The release of (IL-2) completely inhibits the effect of T lymphocytes, which is 100 times stronger than cyclosporine (CsA). In recent years, as a first-line drug for liver and kidney transplantation, it has been marketed in 14 countries including Japan and the United States. Clinical experiments show that it has a good effect in transplantation of heart, lung, intestine, bone marrow, etc. At the same time, FK506 also plays an active role in the treatment of atopic dermatitis (AD), systemic lupus erythematosus (SLE), autoimmune eye disease and other autoimmune diseases.
Immunosuppression in Transplantation: Tacrolimus is a potent immunosuppressant primarily used to prevent organ rejection in transplant patients, including those undergoing kidney, liver, heart, and other solid organ transplants.
Treatment of Autoimmune Diseases: It may also be prescribed in select cases to treat autoimmune disorders, where the immune system mistakenly attacks healthy body tissues, helping to control the overactive immune response.
Atopic Dermatitis Management: In dermatology, tacrolimus is formulated as a topical ointment or cream for the treatment of atopic dermatitis (eczema), reducing inflammation and itching.
Inhibits T-Cell Activation: Tacrolimus binds to the FKBP12 (FK506-binding protein 12) receptor complex, inhibiting the activation of calcineurin, a critical enzyme in T-cell activation and proliferation. This prevents the immune system from mounting a strong response against foreign bodies like transplanted organs.
Suppresses Cytokine Production: By inhibiting T-cell activation, tacrolimus also reduces the production of cytokines, which are signaling molecules that promote inflammation and immune responses. This contributes to its immunosuppressive effects.
Promotes Graft Acceptance: By suppressing the immune system's ability to reject transplanted tissue, tacrolimus allows the graft to be accepted by the recipient's body, reducing the risk of rejection and improving transplant success rates.
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