Chemical Intermediate Wholesale CAS 52-01-7 Raw Material Spironolactone 99%

• Customization: Available
• Powder: Yes
• Customized: Customized
• Model NO.: API
• Certification: GMP, ISO 9001
• State: Solid
• Purity: >99%
• Keyword: Spironolactone
• CAS: 52-01-7
• Mf: C24h32o4s
• Sample: Available
• MOQ: 1kg
• Test Method: HPLC
• Transport Package: Aluminum Foil Bag/Paper Drum
• Specification: 99%
• Trademark: xinlu
• Origin: China
• Production Capacity: 100kg

Product Description

 

Spironolactone, is a kind of potassium preserving diuretic drug. It competes with aldosterone in the cortical epithelial cells of distal tubules and collecting ducts for the aldosterone receptor in the target cells,

so as to inhibit the role of aldosterone in promoting sodium and potassium exchange, increase the excretion of sodium chloride and have a diuretic effect, while potassium ions can be retained. Therefore, spironolactone is a kind of potassium preserving diuretic drug

 

 

 

 

 

Product name:	Spironolactone
CAS No.:	52-01-7
Other name:	Antisterone / Aldactone
Service	Ready to Ship, Drop Shipping service, Excellent Customs clearance Ability MSDS, COA,TDS available OEM Capsule form

1. Diuretic effect: It acts on the distal convoluted tubule and collecting duct of the kidney, competitively inhibiting the action of aldosterone. This leads to increased sodium and water excretion while reducing potassium excretion, resulting in a diuretic effect.
2. Antialdosterone effect: By blocking the binding of aldosterone to its receptor, spironolactone can oppose the actions of aldosterone, which include promoting sodium reabsorption and potassium secretion in the kidneys. This helps to regulate fluid and electrolyte balance.

1. Edema diseases: It is used in the treatment of various edema conditions, such as in congestive heart failure, hepatic cirrhosis with ascites, and nephrotic syndrome. It helps to reduce fluid retention and relieve edema symptoms. In heart failure, it can also improve cardiac function and prognosis by reducing fluid overload and counteracting the harmful effects of aldosterone on the heart and blood vessels.
2. Hypertension: It is often used as an adjunctive therapy in the treatment of hypertension, especially in patients with low - renin hypertension or those who have not achieved satisfactory blood pressure control with other antihypertensive drugs alone. It can help to lower blood pressure by reducing fluid volume and modulating the renin - angiotensin - aldosterone system.
3. Hyperaldosteronism: Whether it is primary hyperaldosteronism (such as due to adrenal adenoma or hyperplasia) or secondary hyperaldosteronism, spironolactone is a key drug for treatment. It can correct the electrolyte imbalance (such as hypokalemia) and hypertension caused by excessive aldosterone secretion.

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