Customization: | Available |
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Powder: | Yes |
Customized: | Customized |
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Product Name | Chloroquine Phosphate |
CAS No. | 50-63-5 |
MF | C18H32ClN3O8P2 |
MW | 515.86300 |
Appearance and shape | White Powder |
Malaria Treatment: It is primarily used as an antimalarial drug to treat and prevent certain types of malaria caused by sensitive strains of the parasite Plasmodium.
Amebiasis Therapy: In some regions, it may also be employed in the treatment of extraintestinal amebiasis (a parasitic infection caused by Entamoeba histolytica).
Immunomodulatory Effects: In some experimental settings, chloroquine phosphate has shown immunomodulatory properties, which are being explored for potential use in autoimmune diseases and cancer therapies, though these applications are still under investigation.
Laboratory Research: It serves as a vital tool in research laboratories for studying cellular processes, including autophagy inhibition, due to its ability to disrupt lysosomal function.
Parasite Inhibition: By accumulating within the acidic digestive vacuole of malaria parasites, chloroquine phosphate disrupts essential heme polymerization, leading to the death of the parasite.
Lysosomal Dysfunction: In cellular contexts, it acts as a weak base that raises the pH of acidic organelles like lysosomes, inhibiting their proteolytic enzymes and disrupting autophagy-a cellular degradation process crucial for maintaining homeostasis.
Antiproliferative Activity: In certain cancer cell lines, chloroquine phosphate has demonstrated antiproliferative effects by inhibiting autophagy, which cancer cells often rely on for survival under stress conditions.
Immunomodulation: Through its impact on immune cell signaling and autophagy, chloroquine phosphate can modulate immune responses, though the specific mechanisms and applications in this regard are still being elucidated.