Factory 99% Epalrestat Powder CAS 82159-09-9 Chemical Intermediate Epalrestat

• Customization: Available
• Powder: Yes
• Customized: Customized
• Model NO.: A986
• Certification: GMP, HSE, ISO 9001, USP, BP
• Suitable for: Elderly, Children, Adult
• State: Powder
• Purity: >99%
• Name: Epalrestat
• CAS: 82159-09-9
• Appearance: White Powder
• Assay: 99%
• OEM: Available
• Sample: Available
• Suitable: Adult
• MOQ: 1g
• Function: Chemical Intermediate
• Transport Package: Foil Bag
• Specification: 99
• Trademark: /
• Origin: China
• Production Capacity: 10000 Kgs Per Month

Product Description

 

Product Name	Epalrestat
Appearance	White Powder
CAS NO.	82159-09-9
Storage	Keep in a cool, dry, dark location

 

Epalrestat is an orally active aldose reductase inhibitor (ARI) designed to treat diabetic complications. It selectively inhibits aldose reductase, the rate-limiting enzyme in the polyol pathway, thereby reducing sorbitol accumulation in nerve tissues.

 

1. Diabetic Neuropathy: Primary indication for managing symptoms like numbness, pain, and tingling in diabetic patients.
2. Diabetic Gastroparesis: Investigated for its potential to alleviate delayed gastric emptying by reducing oxidative stress in enteric nerves.
3. Diabetic Kidney Disease: Explored in preclinical studies for nephroprotective effects via metabolic modulation and reduction of glomerular basement membrane thickening.

1. Neuroprotective Effects: Restores nerve conduction velocity and attenuates oxidative damage by inhibiting aldose reductase, thereby reducing sorbitol-induced cellular dysfunction.
2. Anti-Inflammatory and Antioxidant: Upregulates glutathione levels and activates Nrf2 signaling to counteract oxidative stress in Schwann cells and neuronal tissues.
3. Vascular Protection: Mitigates microvascular complications by stabilizing endothelial function and reducing blood-brain barrier permeability during ischemic events.