Factory Antipsychotic Quetiapine Fumarate Powder CAS 111974-72-2 Quetiapine Fumarate

• Customization: Available
• Powder: Yes
• Customized: Customized
• Model NO.: A39
• Certification: GMP, HSE, ISO 9001, USP, BP
• Suitable for: Adult
• State: Powder
• Purity: >99%
• Name: Quetiapine Fumarate
• Appearance: White Powder
• Assay: 99%
• CAS: 111974-72-2
• OEM: Available
• Sample: Available
• Suitable: Adult
• Function: Antipsychotic
• Transport Package: Foil Bag
• Specification: 99
• Trademark: /
• Origin: China
• Production Capacity: 10000 Kgs Per Month

Product Description

Product Name	Quetiapine fumarate
CAS	111974-72-2
Appearance	white powder
Molecular formula	C46H54N6O8S2
Molecular Weight	883.09
Assay	99%+
Shelf Life	24 months when properly stored

Quetiapine fumarate is an atypical antipsychotic used in the treatment of schizophrenia, bipolar I mania, bipolar II depression, bipolar I depression, and used off-label for a variety of other purposes, including insomnia and anxiety disorders.This means Quetiapine is dopamine, serotonin and adrenergic antagonist, anticholinergic substance and antihistamine.

 

1. Treatment of Schizophrenia: Used as a monotherapy or adjunctive therapy for the management of the positive and negative symptoms associated with schizophrenia.
2. Management of Bipolar Disorder: Prescribed for the treatment of manic or mixed episodes in bipolar I disorder, as well as for the maintenance treatment to prevent recurrence of manic or depressive episodes.
3. Adjunctive Therapy for Major Depressive Disorder: In some cases, it may be prescribed in combination with antidepressants for the treatment of major depressive disorder (MDD) that is not adequately responsive to monotherapy.
4. Off-Label Uses: Although not FDA-approved, quetiapine fumarate has been explored for off-label uses such as augmenting antidepressants in treatment-resistant depression, managing anxiety disorders, and addressing insomnia in certain patient populations.

1. Dopamine and Serotonin Modulation: Quetiapine acts as an atypical antipsychotic by modulating the activity of multiple neurotransmitters, primarily dopamine and serotonin, in the brain. It has high affinity for serotonin 5-HT2A receptors and moderate affinity for dopamine D2 receptors.
2. Antagonistic Action: It exhibits antagonist activity at 5-HT2A receptors, helping to reduce the excessive firing of neurons that may contribute to psychotic symptoms and mood disorders.
3. Balanced Receptor Profile: Quetiapine's balanced receptor profile also includes some affinity for histamine H1, norepinephrine alpha1, and muscarinic M1 receptors, which may contribute to its sedative, hypotensive, and anticholinergic effects, respectively.
4. Modulation of Neurotransmitter Systems: By modulating these neurotransmitter systems, quetiapine can help stabilize mood, reduce hallucinations and delusions, and improve sleep patterns in individuals with psychiatric disorders.
5. Improved Tolerability: Compared to some traditional antipsychotics, quetiapine may offer improved tolerability with fewer extrapyramidal side effects, making it a viable option for patients with a history of sensitivity to these adverse reactions.