| Customization: | Available |
|---|---|
| Powder: | Yes |
| Customized: | Customized |
|
Still deciding? Get samples of $ !
Request Sample
|
Suppliers with verified business licenses
Audited Supplier Audited by an independent third-party inspection agency
| Product Name | Poloxamer |
| Appearance | White Powder |
| CAS NO. | 9003-11-6 |
| Molecular Formula | C5H10O2 |
| Storage | Keep in a cool, dry, dark location |
Poloxamer is a type of novel high-molecular-weight non-ionic surfactant, specifically a polyoxyethylene-polyoxypropylene ether triblock copolymer.
Pharmaceutical Excipient: Poloxamer, particularly Poloxamer 188 (P188), is utilized as a pharmaceutical excipient in clinical applications due to its membrane-sealing effects and inherent biological activities.
Emulsifier and Stabilizer: Poloxamer serves as an emulsifier and stabilizer in the preparation of intravenous emulsions, with Poloxamer 188 being one of the few synthetic emulsifiers used for this purpose.
Temperature-sensitive Gel Formation: Poloxamer, especially Poloxamer 407 (P407) combined with Poloxamer 188, is used in the preparation of temperature-sensitive in situ gels for sustained drug release systems.
Biological Activity Enhancement: Poloxamer 188 has been shown to improve the survival rate of fat grafts and chondrocytes, stimulate metabolic activity of adipocytes, and promote wound healing and cartilage formation in plastic surgery applications.
Drug Delivery System: Poloxamer-based hydrogels are widely used in mucosal, transdermal, and injectable drug delivery systems due to their low toxicity, non-hemolytic nature, non-irritant and non-allergenic properties, and good compatibility with the human body.
Blood-Brain Barrier Penetration: Poloxamer can assist drugs in crossing the blood-brain barrier through various mechanisms, including inhibiting efflux pump systems on the blood-brain barrier and facilitating the active transport of poloxamer-coated nanoparticles into the brain.
){kind=link}