| Customization: | Available |
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| Powder: | Yes |
| Customized: | Customized |
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| Product Name | Ezetimibe |
| Appearance | White Powder |
| CAS NO. | 163222-33-1 |
| Storage | Keep in a cool, dry, dark location |
Ezetimibe is a cholesterol absorption inhibitor with the chemical formula C24H21F2NO3. It is also known by its various synonyms such as Ezetrol, Zetia, and (3R,4S)-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidin-2-one.
Pharmaceutical Industry: Ezetimibe is primarily used in the pharmaceutical industry for the treatment of hypercholesterolemia. It is incorporated into medications designed to lower serum cholesterol levels by inhibiting the absorption of cholesterol from the diet.
Combination Therapies: It is often used in combination with statins or other lipid-lowering agents to enhance the overall efficacy of cholesterol-lowering treatment plans. This allows for a more comprehensive approach to managing hyperlipidemia and reducing the risk of cardiovascular diseases.
Research and Development: Due to its unique mechanism of action, ezetimibe is also of interest in research and development for potential new therapeutic applications, including in the fields of atherosclerosis, metabolic syndrome, and non-alcoholic fatty liver disease.
Cholesterol Absorption Inhibition: Ezetimibe functions by inhibiting the Niemann-Pick C1-Like 1 (NPC1L1) protein, which is responsible for the absorption of cholesterol from the intestine. By blocking this protein, ezetimibe reduces the amount of cholesterol that enters the bloodstream from the diet.
LDL-C Reduction: It also helps to lower low-density lipoprotein cholesterol (LDL-C) levels in the blood. LDL-C is often referred to as "bad" cholesterol because high levels of it are associated with an increased risk of atherosclerosis and cardiovascular diseases.
Adjunct Therapy: In addition to its primary function as a cholesterol absorption inhibitor, ezetimibe can serve as an adjunct therapy in combination with other lipid-lowering agents to achieve greater reductions in LDL-C levels and improve patient outcomes.
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